What are Exosomes?
Exosomes are tiny bubble-like structures in our bodies that work as messengers, they transport important information between cells. The information is composed of molecules such as proteins, lipids and growth factors which help support cell activity, growth and tissue repair. Growth factors assist with growth and repair of bone, muscle, connective tissue and skin. It is these growth and repair capabilities that make exosomes ideal for regenerative medicine and aesthetic treatments.
How do exosomes work?
• Exosomes improve hydration by providing a physically protective barrier and increase dermal thickness.
• Exosomes support collagen growth, improve skin integrity and elasticity. They also help decrease the breakdown collagen.
• Exosomes increase skin regeneration by increasing blood flow to support skin repair processes and wound healing and have powerful anti-inflammatory effects on the skin.
• Exosomes increase fibroblast activity in the dermal layer of the skin which results in collagen and elastin production.
• Exosomes restore and strengthen the skin barrier with lipid and protein delivery.
• Exosomes help control melanocyte activity which helps prevent hyperpigmentation.
• Exosomes reduce oxidative stress and protect against environmental damage with antioxidant enzymes that neutralise free radicals.
• Exosomes facilitate hair restoration by stimulating conversation from telogen (rest phase) to anagen (growth phase) and delay progression to catagen (regression phase). This increases proliferation of hair follicle cells and hair growth.
What are the benefits of exosomes?
Promotes skin regeneration
Exosomes can stimulate the regeneration of skin cells, promoting healing and tissue repair. They contain growth factors, cytokines, and other bioactive molecules that can help accelerate the repair of damaged skin, reduce scarring, and improve overall skin health.
Anti-ageing properties
Exosomes can have a rejuvenating effect on the skin by stimulating collagen and elastin production, which are essential for maintaining skin structure and elasticity. By promoting the production of these proteins, exosomes can help reduce the appearance of fine lines and wrinkles, leading to smoother, firmer skin.
Reduces inflammation
Exosomes have anti-inflammatory effects that can help soothe irritated skin. This makes them beneficial for conditions like acne, eczema, rosacea, and psoriasis. By modulating the immune response, exosomes can reduce redness, swelling and irritation.
Improves skin hydration
Exosomes can enhance the skin’s barrier function, which helps improve moisture retention and hydration. This can be particularly useful for individuals with dry or dehydrated skin, helping to restore a healthy, plump, and glowing complexion.
Accelerates wound healing
Exosomes have been shown to accelerate the healing process in various types of tissue, including skin. They can be particularly useful for healing post-procedure skin, such as after microneedling, laser treatments, or chemical peels, by promoting faster regeneration and reducing downtime.
Brightens the skin
Exosomes may help reduce hyperpigmentation and improve overall skin tone. Some studies suggest that exosomes can help in the regulation of melanogenesis, potentially reducing the appearance of dark spots, age spots, and sun damage.
Supports skin immune function
Exosomes can influence the immune system and modulate the skin’s immune response. This can help in the prevention and treatment of infections, as well as boosting the skin’s ability to defend itself from environmental stressors like pollution and UV radiation.
Potential for treating skin conditions
Some research indicates that exosome therapies could be beneficial for treating specific skin conditions such as acne scars, psoriasis, and even skin cancer-related wounds, thanks to their ability to influence cellular signalling pathways and regeneration processes.
Non-invasive treatment
Unlike some other skin rejuvenation therapies, exosome treatments can be minimally invasive, especially when applied topically or via microneedling or Cool Laser. This allows for improved skin health with little downtime and fewer side effects.
Frequently Asked Questions
Please read the frequently asked questions below which may answer any queries or ease any concerns you may have.
When are exosomes commonly used?
Exosomes are manufactured in serum form. A precise dose of serum is administered immediately following skin resurfacing with an energy-based device such as laser or alongside microneedling. Exosomes reduce the downtime to any resurfacing treatment and improve the overall results.
Where do Exosomes come from?
Bovine colostrum which contains over 250 bioactive elements, is rich in growth factors, and has high levels of antioxidants, proteins and enzymes.
Vegan friendly exosomes come from plants rich in plant proteins and plant genetic material.
What is bovine colostrum?
Bovine colostrum is the milk produced by cows in the first days after giving birth. Rich in antibodies, growth factors, proteins, vitamins and minerals, it has long been used by humans for health benefits that include boosting immunity and improving gastrointestinal health.
Why are bovine colostrum exosomes used?
Bovine growth factors correspond 90% of human growth factors. Growth factors work on the endothelial cells to promote angiogenesis and on the epithelium to cause epithelialisation on fibroblasts to produce collagen
Bovine colostrum has the highest content of antioxidants, anti-inflammatory cytokines and exosomes.
There are over 250 biologically active elements in bovine colostrum including macronutrients (carbohydrates, proteins, vitamins, minerals, antioxidants), biologically active growth factors and exosomes.
What are growth factors?
Growth factors are naturally occurring proteins responsible for stimulating cell proliferation, inflammation modulation, angiogenesis and cellular bioactivity. They regulate the growth, maturation, function and repair of bone, muscle, connective tissue, nervous system and skin.
Growth factors can repair and regenerate aged and damaged skin, promoting collagen and elastin production to reduce lines and wrinkles, while improving the tone and texture of skin.
How are Exosomes delivered?
Exosomes are manufactured in serum form and applied to the treated area after energy devices such as Asclepion Dermablate Erbium YAG Cool Laser or alongside microneedling. Exosomes reduce the downtime to any resurfacing treatment and improve the overall results.
The exosome range we use at LASE is Purasomes
Nutri complex Purasomes NC 150+ best for older skin with more general damage including elastosis, fine lines and wrinkles, age spots, mature skin, dry and dehydrated skin, acne scarring. The ingredients include 20 billion exosomes from bovine colostrum, 20 growth factors, amino acids, hyaluronic acid, vitamins and minerals.
Skin glow complex Purasomes SGC 100+ best for pigmentation, oily skins, young skin, melasma and acne scarring. The ingredients include 20 billion exosomes from bovine colostrum, 20 growth factors, synthetic peptides, glutathione, antioxidants, hyaluronic acid and brightening agents to rebuild flawless skin complexion.
hair and scalp complex Purasomes HSC50+ best for hair. Loaded with bioactive elements, it targets hair follicles directly to strengthen of the dermal papilla to reactive normal hair growth function, leading to less hair loss, enhanced scalp health and an improvement in hair quality.
About Dermaroma
Dermoaroma is the manufacturer of Purasomes. Based in Italy, this innovative company designs solutions to rearchitect the structure and restore the function of ageing and problematic skin. Achieved by advancing cell therapies to maximum efficacy and complete safety, Dermoaroma has 14 registered patents in regenerative aesthetics, regenerative medicine and wound management relating to its AMPLEX Plus technology.
Ethics
AMPLEX Plus is a patented system of obtaining the exosomes using the strictest and safe technology. The bovine colostrum used in AMPLEX Plus comes from cattle bred in an Organic Certified family-run farm in Italy. The cattle are grass fed and the colostrum is harvested one to five hours after parturition to ensure it is of the best quality.
Before harvesting, significant steps are taken to ensure that no calves are deprived of colostrum that is needed to support their growth and development.
How is AMPLEX Plus created?
The Dermoaroma team spent nine years working with leading European scientists to develop a skin and hair care treatment that is safe, sustainable and natural.
The resulting AMPLEX Plus technology utilises bovine colostrum, harvested from grass-fed cattle on an Italian Organic Certified family farm within the first one to five hours after parturition. The process used ensures that calves are never deprived of colostrum, which is key for their growth and development.
It is then delivered and processed in specially equipped transport to the Dermoaroma production site within 24 to 48 hours.
When it arrives, the bovine colostrum is purified so only the most potent biologically active elements are utilised. Using a centrifuge, exosomes and growth factors are isolated, allowing impurities such as fat, dead cells and debris to be discarded.
The exosomes and growth factors then go through a reliable dehydrating process, which allows them to be stored at room temperature without comprising their integrity. The end product is a 5ml vial containing 200mg of 20 billion exosomes and 20 of the most potent growth factors ready for use.
Is AMPLEX Plus safe?
Thanks to its swift harvesting process and meticulous purification system, AMPLEX Plus has been found to be completely safe and non-toxic.
It contains no artificial components, does not have a risk of transmitting infections and no ethical concerns with its use have been identified.
As a lyophilised product, AMPLEX Plus can be easily transported and stored.
About DermaFocus
DermaFocus is the UK distributor of Purasomes. Specialising in distributing evidence-based regenerative aesthetic products, the company is dedicated to empowering aesthetic practitioners to embrace regenerative treatments that enhance natural beauty, and seamlessly integrate into their clinic offering. DermaFocus believes in the power of science, research and cutting-edge technology to truly enrich the lives of both patients and professionals.
Common features of polynucleotides and exosomes
• Natural sources as they are extracted from living animals.
• Can contain nucleic acids such as DNA and RNA.
• Are involved in crucial cellular functions, including gene expression, cell signalling, and immune regulation.
• Actively contributes to the intercellular communication allowing information exchange and coordination.
• Proven ability to promote tissue regeneration and healthy cell proliferation.
• Significant capacity to reduce chronic inflammation
• Products with low immunogenicity produced after application of strict purification protocols.
• Ideal adjectives to boost the final TREATMENT RESULTS when energy devices are used.
• Lead to natural results that depend on patient’s biological status.
LASE INTENSE Skin and Hair treatments
Our LASE Intense Skin and LASE Intense Hair treatments packages are bespoke but commonly include skin and hair care products and supplements, polynucleotides, Cool Laser or microneedling, hyaluronic acid and Purasomes. Your precise combination and number of treatments will be discussed and planned at your consultation. However, treatments are commonly planned in courses of 3.
This multi-dimensional approach is designed to amplify regenerative capabilities through 3 prescriptive stages:
Optimisation
Optimising the skin with high quality skincare products will prime the skin ready for the next stages. As part of the LASE Intense Skin protocols and the LASE Intense Hair protocols, you may be advised on prescriptive products to get your skin and scalp prepared for the next step.
Supplements may also be included in your bespoke package
Stimulation
Once the skin is primed, we treatment with Cool Laser or microneedling (I use Cool Laser on the face neck and chest and microneedling on the scalp)
Asclepion Dermablate Erbium YAG Cool Laser offers precise ablation of 2940nm wavelength which has a high absorption of water in the skin. This specific ability allows for resurfacing with minimal thermal spread while providing an effective contractile force similar to CO2 lasers.
Unlike CO2 lasers, the Cool Laser’s limited coagulation preserves the skins natural regenerative ability by allowing controlled plasma exudate, which acts as a natural healing catalyst.
Amplification
Immediately after the Asclepion Dermablate Erbium YAG Cool Laser or microneedling we amplify the healing and optimise end results with a LASE Intense Skin or LASE Intense Hair combination protocol of biostimulating Purasomes and hyaluronic acid.
Hyaluronic acid enhances hydration and encourages a healthy environment for cell renewal while Purasomes accelerate healing and stimulate the fibroblasts in your skin to produce collagen and elastin.
Q&A
How many treatments do I need?
After a course of 3 purasomes treatment sessions in combination with a skin resurfacing treatment such as Cool Laser or microneedling, patients can expect to see significant improvement of their skin and hair concerns, with results expected to last 9 to 12 months. Continued treatment every 6 months is recommended to maintain results.
Are Purasomes suitable for everyone?
Each of the products within the Purasomes can be used on all skin types. We do not recommend using Purasomes on patients who are pregnant or breastfeeding.
As the colostrum used in the AMPLEX Plus technology is obtained from cattle, Purasomes may be unsuitable for some vegan patients.
AMPLEX Plus is Halal and Kosher certified.
What is the cost of the combined treatments?
The cost is dependent on what products and treatments we choose when creating your bespoke package. The cost of each individual product or treatment is reduced when sold as part of the package.
Get In Touch
Follow Us
