Regenerative medicine in aesthetics is revolutionising the way we approach skin rejuvenation, offering new solutions to repair and revitalise the skin at a cellular level.
By using advancements in regenerative medicine, these treatments take a multi-layered approach to restoring youthful vitality to the face and skin.
The most powerful innovations are the use of combination therapies, which pair the latest biostimulating technologies to stimulate skin repair and improve overall treatment results.
Polynucleotides and exosome therapy are at the front of this, providing effective benefits for skin regeneration and rejuvenation.
In this blog, we’ll explore both approaches, helping you understand what’s involved so you can make an informed decision about the best options.
Polynucleotides
The first regenerative treatment we’re exploring is polynucleotides – one of the fastest-growing innovations in the medical aesthetics industry.
What are Polynucleotides?
Biologically, polynucleotides are chains of nucleotides. DNA and RNA are examples of polynucleotides with specific biological functions.
Polynucleotides used in aesthetic treatments are highly purified DNA fractions derived from salmon trout gonads. Hence why polynucleotide treatments are sometimes referred to as salmon sperm facials.
The use of polynucleotides in aesthetic medicine is an exciting breakthrough in regenerative treatments, offering a powerful way to improve the overall condition of the skin.
Although they’re gaining attention in the world of aesthetics now, polynucleotides have a long-established history in medicine.
First introduced in 1983 as part of gene therapy, they were used to treat and prevent a range of genetic disorders and infections. By the early 1990s, they were recognised for their wound-healing properties, and in 2005, they became approved for use as injectable treatments.
Over the years, polynucleotides have been the focus of over 90 clinical trials, consistently demonstrating their effectiveness.
Their proven track record has firmly established their place in both medical and aesthetic fields, making them a trusted choice for skin rejuvenation.
How do polynucleotides work?
Polynucleotides encourage physiological repair and fast healing due to their biostimulating properties.
Predominantly derived from highly purified salmon DNA, polynucleotides are designed to stimulate fibroblasts in the dermal layer of the skin, this promotes collagen and elastin growth and stimulates skin tissue repair which results in increased elasticity and firmness in the skin.
They also reduce inflammation and balance melanocyte activity (skin pigmentation) which can result in a more even skin tone.
What can polynucleotides be used for?
Polynucleotides are used to treat skin laxity, fine lines and wrinkles, and some skin conditions such as rosacea and eczema.
Polynucleotides are also used to reduce the appearance of surgical and acne scarring. They can also be used in the scalp to treat thinning hair and to promote healthy hair growth.
At LASE, we most often use polynucleotides in combination with other biostimulating treatments to provide powerful and effective solutions for most skin concerns. Treatments are carried out around 4 weeks apart and a course of treatments is recommended. You can read more about Polynucleotides here.
Exosomes
Building on the power of regenerative medicine, exosomes offer another groundbreaking approach to revitalising the skin.
What are Exosomes?
Biologically, exosomes are extracellular vesicles that are found in bodily fluids and have specialised functions such as intercellular communication.
In regenerative medicine and aesthetic treatments exosomes work as tiny messengers which transport important information between cells.
The information is composed of bioactive molecules growth factors, which helps facilitate cellular communication and tissue repair.
How do Exosomes work?
Exosomes are key to the body’s natural regenerative processes, playing an important role in activities such as tissue repair and collagen production.
They help improve skin texture, improve healing, and reduce the appearance of wrinkles.
However, as we age, the effectiveness of exosomes declines, leading to common problems like wrinkles and sagging skin.
By delivering these powerful molecules directly to the cells that need them, exosome therapy can kickstart rejuvenation, restoring a more youthful complexion.
What are the benefits of Exosomes?
There are numerous benefits of exosomes which we’re exploring below:
- Exosomes provide hydration by creating protective environments for cells and increasing dermal thickness.
- Exosomes encourage collagen synthesis and improve skin integrity, elasticity, and slows the breakdown down of collagen.
- Exosomes reduce photodamage by reducing melanin in our skin.
- Exosomes regenerate skin by increasing blood flow for skin repair processes and improved wound healing.
- Exosomes reduce inflammatory processes and are also used for hair restoration and increasing hair growth.
- Increasing skin hydration and fibroblast activity and accelerate healing through various pathways.
- Regulating collagen production depending on the timing of skin wound healing; during the initial phase, promote the production of mature collagen fibres.
- Restoring and strengthening skin barrier with lipid and protein delivery.
- Reducing prolonged inflammation.
- Controlling melanocyte activity preventing hyper-pigmentation.
- Reducing oxidative stress and protecting against environmental damage with antioxidant enzymes that neutralise free radicals.
When are Exosomes commonly used?
Exosomes are used immediately after microneedling or skin resurfacing with an energy-based device such as laser.
At LASE, we treat the skin with Purasomes, which are specially formulated exosome-based serums designed to accelerate the body’s natural healing processes and promote skin and hair rejuvenation. This is done after Cool Laser on the face and body, and following microneedling on the scalp.
After a series of three to five Purasomes treatment sessions, patients can expect to see significant improvement of their skin and hair concerns, with results expected to last 9 to 12 months. Continued treatment every 6 months is recommended as maintenance.
Where do Exosomes come from?
Exosomes come from animal milk, which contains over 250 bioactive elements, rich in growth factors, high levels of antibodies (Ab), antioxidants, cytokines, lactoferrin, and lactoperoxidase.
Vegan-friendly exosomes come from plant proteins and plant genetic material.
Why do we use Bovine Colostrum Exosomes?
Bovine growth factors correspond to 90% of human growth factors. These growth factors work on the endothelial cells to promote angiogenesis and on the epithelium to cause epithelialisation in fibroblasts to produce collagen and elastin.
Bovine colostrum exosomes also have the highest content of antioxidants, anti-inflammatory cytokines, and other biologically active elements such as macronutrients, immune-stimulating factors, and more.
What are growth factors?
Growth factors are naturally occurring proteins responsible for stimulating cell proliferation, inflammation modulation, angiogenesis, and cellular bioactivity.
They regulate the growth, maturation, function, and repair of bone, muscle, connective tissue, nervous system, and skin.
What is Bovine Colostrum?
Bovine colostrum is the milk produced by cows in the first days after giving birth. It is rich in antibodies, growth factors, proteins, vitamins, and minerals, and has long been used by humans for health benefits, such as boosting immunity and improving gastrointestinal health.
The biologically active elements present in bovine colostrum include carbohydrates, proteins, fats, vitamins, minerals, antioxidants, cytokines, lactoferrin, lactoperoxidase, lysozyme, IGs, growth factors and exosomes.
What are the ethics around the use of Bovine Colostrum?
The bovine colostrum used in AMPLEX Plus comes from cattle bred in an Organic Certified family-run farm in Italy. The cattle are grass fed and the colostrum is harvested one to five hours after parturition to ensure it is of the best quality.
Before harvesting, significant steps are taken to ensure that no calves are deprived of colostrum that is needed to support their own growth and development.
How Is AMPLEX Plus Created?
The DermaFocus team spent nine years working with leading European scientists to develop a skin and hair care treatment that is safe, sustainable, and natural.
The resulting AMPLEX Plus technology utilises bovine colostrum, harvested from grass-fed cattle on an Italian Organic Certified family farm within the first one to five hours after parturition. The process used ensures that calves are never deprived of colostrum, which is key for their growth and development.
It is then delivered and processed in specially equipped transport to the DermaFocus production site within 24 to 48 hours.
When it arrives, the bovine colostrum is purified so only the most potent biologically active elements are utilised. Using a centrifuge, exosomes and growth factors are isolated, allowing impurities such as fat, dead cells and debris to be discarded.
The exosomes and growth factors then go through a reliable dehydrating process, which allows them to be stored at room temperature without compromising their integrity. The end product is a 5ml vial containing 200mg of 20 billion exosomes and 20 of the most potent growth factors ready for use.
Is AMPLEX Plus safe?
Thanks to its swift harvesting process and meticulous purification system, AMPLEX Plus has been found to be completely safe and non-toxic.
It contains no artificial components, does not have a risk of transmitting infections and no ethical concerns with its use have been identified.
As a lyophilised product, AMPLEX Plus can be easily transported and stored.
Are Purasomes suitable for everyone?
Purasomes is the brand name for DermaFocus exosomes. Each product within the Purasomes range is suitable for all skin types. However, we do not recommend using Purasomes on patients who are pregnant or breastfeeding.
Since the colostrum used in AMPLEX Plus technology is derived from cattle, Purasomes may not be suitable for vegan patients.
For added reassurance, AMPLEX Plus is Halal and Kosher certified.
Explore the exosome range by DermaFocus here.
About DermaFocus
DermaFocus is the UK distributor of Purasomes, a leading name in regenerative aesthetic products. By specialising in scientifically-backed solutions, DermaFocus empowers aesthetic practitioners to embrace treatments that improve natural beauty.
The Purasomes Range:
Nutri Complex (NC 150+)
Ideal for mature skin or skin showing signs of aging, such as:
- Elastosis, fine lines, and wrinkles
- Age spots, dryness, and dehydration
- Acne scarring and general skin damage
Key ingredients:
- 20 billion exosomes from bovine colostrum
- 20 growth factors, amino acids, DMAE, hyaluronic acid
- Vitamins and oligo-minerals
Skin Glow Complex (SGC 100+)
Best suited for youthful skin concerns, including:
- Pigmentation and melasma
- Oily skin and acne scarring
Key ingredients:
- 20 billion exosomes from bovine colostrum
- 20 growth factors, synthetic peptides, glutathione
- Antioxidants and hyaluronic acid
Hair and Scalp Complex
A targeted solution for promoting healthy hair and scalp.
Common Features of Polynucleotides and Exosomes
Polynucleotides and exosomes share several features that contribute to their effectiveness in cellular repair. Below, we highlighting some of these common traits:
- Natural sources as they are extracted from living animals.
- Can contain nucleic acids such as DNA and RNA.
- Are involved in crucial cellular functions, including gene expression, cell signalling, and immune regulation.
- Actively contributes to intercellular communication allowing information exchange and coordination.
- Proven ability to promote tissue regeneration and healthy cell proliferation.
- Significant capacity to reduce chronic inflammation.
- Products with low immunogenicity produced after application of strict purification protocols.
- Ideal adjectives to boost the final outcome when energy devices are used.
- Lead to natural results that depend on the patient’s biological status.
Regenerative Medicine in Skin Rejuvenation: Polynucleotides & Exosomes
Regenerative aesthetics, driven by the power of polynucleotides and exosome therapy, is transforming the landscape of skin rejuvenation.
These innovative treatments offer a natural, science-backed approach to improving skin health, promoting repair, and achieving a more youthful appearance.
With this in mind, aesthetic practitioners can provide patients with effective, results-driven options that align with the growing demand for regenerative treatments.
At LASE, we recommend a consultation before deciding on any treatment option so we can determine what is right for your needs and goals. With over 40 years of experience in the industry, you can be sure you’re in safe hands. Get in touch with our team of experts to find out more.
Recent Comments